By Trevor M. Penning, J. Mark Petrash
content material: part 1: basic evaluate ; 1. advent and review of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic issues ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the cleansing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO comparable cancer causing agents ; five. Competing Roles of Reductases within the detoxing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the energetic Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated by way of the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative rigidity ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic relief vs Adduction with Lysine ; thirteen. using mammalian mobile traces to enquire the position of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the strain reaction AND phone SIGNALING ; 14. Aldose Reductase and the tension reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory indications ; sixteen. Aldo-Keto Reductases within the rigidity reaction of the Budding Yeast Saccharomyces cerevisiae
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ACS Symposium Series; American Chemical Society: Washington, DC, 2003. ch002 MeG was prepared by hydrolysis of pyruvic aldehyde dimethylacetal with sulfuric acid followed by azeotropic distillation with water. 3-Deoxyglucosone, glucosone, 3-deoxyxylosone, xylosone, and 4-hydroxynonenal were synthesized by literature procedures. All other aldehydes werefromSigma. Purification of AKR1A1 and AKR1B1 A K R 1 A 1 and A K R 1 B 1 were purified from human liver and skeletal muscle, respectively, as described previously (24-26).
Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash