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Download Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash PDF

By Trevor M. Penning, J. Mark Petrash

ISBN-10: 0841219702

ISBN-13: 9780841219700

ISBN-10: 0841238464

ISBN-13: 9780841238466

content material: part 1: basic evaluate ; 1. advent and review of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic issues ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the cleansing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO comparable cancer causing agents ; five. Competing Roles of Reductases within the detoxing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the energetic Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated by way of the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative rigidity ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic relief vs Adduction with Lysine ; thirteen. using mammalian mobile traces to enquire the position of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the strain reaction AND phone SIGNALING ; 14. Aldose Reductase and the tension reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory indications ; sixteen. Aldo-Keto Reductases within the rigidity reaction of the Budding Yeast Saccharomyces cerevisiae

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Vander Jagt, D. ; Taylor, K. ; Hunsaker, L. A. J. Biol. Chem. 1990, 265, 20982-20987. 25. Vander Jagt, D. ; Hunsaker, L. ; Stangebye, L. ; Deck, L. M . J. Biol. Chem. 1990, 265, 10912-10918. 26. Vander Jagt, D. ; Taylor, K. K; Hunsaker, L. A. J. Biol. Chem. 1992, 267, 4364-4369. 27. Vander Jagt, D. ; Hunsaker, L. A. Adv. Exp. Med. Biol. 1993, 328, 279288. 28. Vander Jagt, D. ; Torres, J. ; Hunsaker, L. ; Deck, L. ; Royer, R. E. Adv. Exp. 1996, 414, 491-497. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003.

11. ; Barlocco, D. Med Res Rev 1999, 19, 3-23. 12. Pfeifer, M . ; Schumer, M . P. Diabetes 1995, 44, 1355-1361. 13. Srivastava, S. ; Hair, G. ; Das, B. Proc. Natl. Acad. Sci. USA 1985 82, 7222-72226. 14. ; Srivastava, S. K. Diabetes 1985, 34, 1145-1151. 15. Srivastava, S. ; Petrash, J. ; Sadana, I. ; Ansari, N . ; Partridge, C. A. Curr. Eye Res. 1983, 2, 407-410. 16. ; Boss, G. ; Lane, M . F. 1987 Diabetologia 30, 222-227. 17. ; Ansari, N. ; Srivastava, S. K. Biochem. Pharmacol. 1990, 39, 1115-1124.

ACS Symposium Series; American Chemical Society: Washington, DC, 2003. ch002 MeG was prepared by hydrolysis of pyruvic aldehyde dimethylacetal with sulfuric acid followed by azeotropic distillation with water. 3-Deoxyglucosone, glucosone, 3-deoxyxylosone, xylosone, and 4-hydroxynonenal were synthesized by literature procedures. All other aldehydes werefromSigma. Purification of AKR1A1 and AKR1B1 A K R 1 A 1 and A K R 1 B 1 were purified from human liver and skeletal muscle, respectively, as described previously (24-26).

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Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash

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