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Download Biochemistry of Signal Transduction and Regulation, Second by Gerhard Krauss(auth.) PDF

By Gerhard Krauss(auth.)

ISBN-10: 3527303782

ISBN-13: 9783527303786

ISBN-10: 3527600051

ISBN-13: 9783527600052

Now the up to date moment variation of this bestselling identify is out there as softcover!

Intracellular sign transduction, law of mobile actions, tumor formation, apoptosis - how do they paintings? those questions became a valuable subject in Biology and organic Chemistry. the significance of this box is reflected within the 1999 Nobel prize for body structure that went to G. Blobel for his findings in protein shipping regulation.

during the last decade there was nice development within the figuring out of the molecular foundation of sign transduction, and plenty of proof at the moment are easy wisdom for each medicinal chemist, biochemist, and biologist. considering an imperative description of mobile law and sign transduction is scarcely coated in textbooks, this ebook fills a true hole. ranging from the rules of gene legislation and rules of enzyme task, the subjects of this publication conceal functionality, constitution, and critical building of signalling pathways plus a close description of some of the sorts of providers resembling moment messengers, protein kinases, and transmembrane receptors. imperative mobile strategies like cellphone cycle rules, oncogenesis and apoptosis are mentioned in gentle of the homes of the signalling molecules concerned. With didactic ability and readability the writer relates the saw organic phenomena to the underlying biochemical processes.
This ebook is admittedly books: legislation and sign Transduction.

Chapter 1 The law of Gene Expression (pages 1–88):
Chapter 2 The legislation of Enzyme job (pages 89–118):
Chapter three functionality and constitution of Signaling Pathways (pages 119–147):
Chapter four Signaling by means of Nuclear Receptors (pages 148–172):
Chapter five G?Protein Coupled sign Transmission Pathways (pages 173–215):
Chapter 6 Intracellular Messenger elements: “Second Messengers” (pages 216–246):
Chapter 7 Ser/Thr?Specific Protein Kinases and Protein Phosphatases (pages 247–285):
Chapter eight sign Transmission through Transmembrane Receptors with Tyrosine?specific Protein Kinase task (pages 286–323):
Chapter nine sign Transmission through Ras Proteins (pages 324–349):
Chapter 10 Intracellular sign Transduction: the Protein Cascades of the MAP Kinase Pathways (pages 350–357):
Chapter eleven Membrane Receptors with linked Tyrosine Kinase task (pages 358–376):
Chapter 12 different Receptor periods (pages 377–384):
Chapter thirteen legislation of the mobilephone Cycle (pages 385–419):
Chapter 14 Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes (pages 420–454):
Chapter 15 Apoptosis (pages 455–472):
Chapter sixteen Ion Channels and sign Transduction (pages 473–493):

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Extra resources for Biochemistry of Signal Transduction and Regulation, Second Edition

Example text

In the absence of Cu+ a specific binding of the ACE recognition sequence is not possible, and the expression of the metallothionein gene is inhibited. , 1999). An increase of Ca2+ in the form of a Ca2+ signal (see Chapter 6) leads to reduced affinity of the repressor for its DNA element and to an increased expression of the target gene. 3 Binding of Inhibitory Proteins Specific DNA-binding proteins can be constrained in their ability to function as gene regulators by complex formation with inhibitor proteins.

3 & Fig. 4). The structure of GAL4 complexed with its recognition sequence indicates that the Zn2+ ions mainly act to stabilize the small globular GAL4 protein and to orient the recognition helix correctly within the major groove. Overall, the zinc-binding motifs display a great variety of structural diversity. The occurrence of a zinc binding motif can often be predicted based solely on a characteristic series of Cys and His residues in a protein sequence. The complexation of a Zn2+ by His and Cys residues serves to bring the recognition element of the protein into a stable and unambiguous position relative to the DNA, thereby enabling specific contacts with the recognition sequence.

The eucaryotic transcription factor NF O B in complex with DNA. Shown is the structure of a fragment of the p50 subunit of NF O B complexed with the recognition sequence. p50 of NF O B binds DNA as a dimer. Each of the subunits contains a bundle of g -sheets which envelops the DNA so that only the minor groove is exposed. After Ghosh et al. (1995), with permission. 2 The Nature of the specific Interactions in Protein-Nucleic Acid Complexes The binding of a protein to nucleic acid is accomplished by weak, non-covalent interactions.

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Biochemistry of Signal Transduction and Regulation, Second Edition by Gerhard Krauss(auth.)

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