By Nils Metzler-Nolte
This booklet provides a special creation into the sphere of bioinorganic chemistry via functional laboratory experiments. themes contain many facets of contemporary bioinorganic chemistry equivalent to version structures for metalloenzymes, biosensors, steel bioconjugates and metal-based medications. every one bankruptcy incorporates a short advent, via specific experimental methods, accomplished with all useful history info for the coed in addition to their teachers. A necessary complement to plain textbooks of inorganic and bioinorganic chemistry crucial for all teachers instructing laboratory classes regularly and inorganic chemistry
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For genomic engineering, it is necessary to cleave DNA strands to remove or introduce oligonucleotide sequences. On the other hand, destruction of the DNA of malignant cells might be beneficial in the chemotherapy of cancer. Among the different methods to study DNA manipulation and degradation, gel electrophoresis is a very simple means to analyze the effect of metal complexes and additives on oligonucleotides. In this chapter, you will learn how to apply this method to study the effect of copper and manganese complexes on plasmid DNA.
Yamada, Y. Tanaka, Y. Yoshimoto, S. Kuroda, I. Shimao, Synthesis and properties of diamino-substituted dipyrido[3,2-a:20 ,30 -c]phenazine, Bull. Chem. Soc. Jpn. 1992, 65, 1006–1011.  B. P. Sullivan, D. J. Salmon, T. J. Meyer, Mixed phosphine 2; 20 -bipyridine complexes of ruthenium, Inorg. Chem. 1978, 17, 3334–3341.  E. Amouyal, A. -C. -P. Sauvage, Synthesis and study of a mixed-ligand ruthenium(II) complex in its ground and excited states: bis(2; 20 bipyridine)(dipyrido<3,2-a:20 ,30 -c>phenazine-N4 N5 /ruthenium(II), Dalton Trans.
Bioinorganic Chemistry: A Practical Course by Nils Metzler-Nolte