By Meir Shinitzky
An up-to date assessment of uncomplicated examine on biomembranes. during this quantity, top-rated specialists within the box examine crucial structural and practical facets of biomembranes: - Membrane Lipids and Aging
- Membrane-bound Enzymes
- Ion Channels in organic Membranes
- Anion Exchangers of Mammalian cellphone Membranes
- range of shipping Mechanisms in Bacteria.
the quantity is a wonderful complement to 'Biomembranes - actual Aspects', additionally edited by means of Meir Shinitzky. jointly those books supply a complete floor for figuring out advanced physiological processes.
Meir Shinitzky, Ph.D., is a Professor of Biophysics within the division of Membrane study and Biophysics, The Weizmann Institute of technology, Rehovot, Israel. considering that 1971, his examine has keen on quite a few features of membrane constitution and dynamics. at present his major curiosity is in manipulation of membrane fluidity for scientific diagnoses and coverings. He has released generally and is stated all over the world as one of many top specialists within the more and more major box of biomembrane examine.
Chapter 1 Membrane Lipids and getting older (pages 1–82): Hilary R. Shmeeda, Elisabeth B. Golden and Yechexkel Barenholz
Chapter 2 Membrane?Bound Enzymes (pages 83–197): G. Lenaz and M. Degli Esposti
Chapter three Ion Channels in organic Membranes – common ideas (pages 199–296): Rami Rahamimoff, Simona Ginsburg, Gavriel Barkai, Boaz cook dinner, Jackie Edry?Schiller, Igor Kaiserman, Alon Meir, Michal Roll, Mary Kate Worden and Nilly Yakir
Chapter four Anion Exchangers of Mammalian mobilephone Membranes (pages 297–327): Z. Ioav Cabantchik
Chapter five range of shipping Mechanisms in micro organism (pages 329–379): Bert Poolman, Douwe Molenaar and Wil N. Konings
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Extra info for Biomembranes: Structural and Functional Aspects
The “error catastrophe” theoiy was proposed by Orgel in 1963 and revised in 1970. It suggested that errors in the enzymes responsible for protein synthesis would lead to production of faulty proteins. Altered proteins are found in old organisms, but the differences seem to be due to changes in conformation rather than sequence. Studies by Hayflick [ 1591 of inbred mouse strains have indicated that about 50% of the variance associated with longevity is due to genetically related factors. Rattan and Clark  contend that stochastic events are the predominant factors which determine the rate of aging.
Slotte et al. R. S h e e d a et al. 90% of total cell-free cholesterol ) is redistributed in 90 min into an intracellular pool which is then available for esterification. The time frame is of the same order of magnitude as cholesterol transfer between phospholipid vesicles. This supports the dogma that sphingomyelin is a major determinant of the distribution of cholesterol between membranes of intact cells (review by [15,455]). Studies of cholesterol transfer between microsomes and liposomes of either PC or SPM by Bhuvanaswaran and Mitropoulos  showed that membranes enriched with SPM exhibit the same rate of cholesterol absorption from donor membranes as membranes enriched with PC.
Strate that the aging of the cells in culture is accompanied by a reduction in the muscarinic binding capacity and by alterations in the proportion of high- and low-affinity states toward muscarinic agonists. In addition, striking changes in the mode of coupling of the receptors with guanine nucleotide binding protein(s) (the G proteins) were observed. These changes occur concomitantly with alterations in the lipid composition of the cultured myocytes. When aging cultures were treated with liposomes containing egg PC, 14-day-old cultures demonstrated muscarinic receptors properties similar to those of young cultures.
Biomembranes: Structural and Functional Aspects by Meir Shinitzky